Olivier J Becherel Selected Research

Apraxias (Dyspraxia)

6/2019	Disruption of Spermatogenesis and Infertility in Ataxia with Oculomotor Apraxia Type 2 (AOA2).
1/2015	Senataxin controls meiotic silencing through ATR activation and chromatin remodeling.
1/2014	R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias.
1/2013	Senataxin protects the genome: Implications for neurodegeneration and other abnormalities.
3/2010	CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.
11/2009	Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.
6/2007	Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage.

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Olivier J Becherel Research Topics

Disease

7	Apraxias (Dyspraxia) 06/2019 - 06/2007
6	Ataxia (Dyssynergia) 01/2015 - 06/2007
2	Atrophy 06/2019 - 01/2013
2	autosomal recessive 1 Spinocerebellar ataxia 06/2019 - 07/2006
2	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2015 - 03/2006
2	Genomic Instability 01/2013 - 05/2004
2	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2010 - 11/2009
1	Oculomotor Nerve Diseases (Oculomotor Nerve Palsy) 06/2019
1	Cerebellar Ataxia (Dysmetria) 06/2019
1	Infections 05/2015
1	Infertility (Sterility) 01/2014
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2013
1	Nervous System Diseases (Neurological Disorders) 07/2006

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2015 - 03/2006
4	DNA (Deoxyribonucleic Acid)IBA 01/2015 - 11/2009
2	RNA (Ribonucleic Acid)IBA 01/2015 - 01/2014
1	alpha-Fetoproteins (alpha-Fetoprotein)IBA 06/2019
1	Antiviral Agents (Antivirals)IBA 05/2015
1	ChromatinIBA 01/2015
1	Histones (Histone)IBA 01/2015
1	Nucleosomes (Nucleosome)IBA 01/2015
1	Carrier Proteins (Binding Protein)IBA 01/2015
1	DNA HelicasesIBA 01/2015
1	Fetal Proteins (Fetoprotein)IBA 01/2013
1	A-Form DNA (A-DNA)IBA 11/2009
1	Nuclear Proteins (Protein, Nuclear)IBA 06/2007
1	Complementary DNA (cDNA)IBA 05/2004
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 05/2004

Therapy/Procedure

2	Ligation 03/2010 - 11/2009